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فرقہ واریت کا خاتمہ : پہلا قدم

آج کے دور میں مسلمان کئی فرقوں میں بٹ چکے ہیں اگرچہ ان کی اکثریت اسلام کے بنیادی عقائد اور عبادات پر متفق ہے مگر فروعی اختلافا...

Bypass Surgery Might Be History Soon...


In a ground breaking discovery that may eventually render bypass surgery history, 
researchers at Tel Aviv University [Arbas are busy in making tallest 
 in word and fighting among 
] have shown that an injected protein can 
regrow blood vessels in the human heart. 
In heart disease, blood vessels are either clogged or die off, starving the heart of
oxygen and leaving it highly susceptible to a cardiac attack. 
Dr. Britta Hardy of TAU's Sackler School of Medicine and her team of researchers 
have developed a protein-based injection that when delivered straight to muscles 
in the body, sparks the regrowth of tiny blood vessels.

The new vessels in the heart could give millions of people  around 
 the world a new lease on life. 
"The biotechnology behind our human-based protein therapy is very complicated, 
but the goal is simple and the solution is straightforward. We intend to inject our 
 drug locally to heal any oxygen-starved tissue.

So far in animal models, we've seen no side effects and no inflammation 
 following our injection of the drug into the legs. The growth of new blood 
vessels happens within a few weeks, showing improved blood circulation,"
 said Hardy.

The protein solution can also be added as a coating to a stent. Usually, 
the implantation of a stent is accompanied by a high risk for blood clots, 
which necessitates the use of blood thinners.

"We could coat a stent with our peptide, attracting endothelial stem cells to 
form a film on the surface of the stent. These endothelial cells on the stent 
would eliminate the need for taking the blood thinners that prevent blood 
clots from forming," said Hardy.

If investment goals are met, the researchers are hoping that toxicity studies and 
Phase I trials could be complete within two years.

The researchers began the study for preventing leg amputations, positing that 
proteins from the human body could be used to trigger the growth of new blood vessels.

Hardy started by studying a library of peptides and testing them in the laboratory 
and later confirmed initial results. She then took some of the isolated and 
synthesized peptides and tested them in diabetic mice whose legs 
were in the process of dying.

Although diabetes is known to decrease blood circulation, Hardy found that 
her therapy reversed the decrease. "Within a short time we saw the formation 
 of capillaries and tiny blood vessels.

After three weeks, they had grown and merged together with the rest of the
circulatory system," she said. In mice with limited blood circulation, she was 
 able to completely restore blood vessels and save their legs. 
It was then a short step to studying the applicability of the research to 
cardiac patients. "It''s pretty obvious if there is regrowth or not. 
Our technology promises to regrow blood vessels like a net, and a heart that 
grows more blood vessels becomes stronger. It's now imaginable that, in the 
 distant future, peptide injections may be able to replace bypass surgeries," 
concluded Hardy. 
The study has been published in Biochemical Pharmacology
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